Mix and match vaccination. PRD

 

 The Department of Medical Sciences joined hands with Siriraj Hospital in researching the level of immunity in serum from people who have been vaccinated with different brands, which also includes the "mix and match" vaccinations and the heterologous prime-boost with a third dose. The researchers are focusing on the Delta variant, which has a 90% infection rate in Thailand. They use the Plaque Reduction Neutralization Test (PRNT), which is a standard test that operates in laboratories that work at biosafety level 3 (BSL-3), to find the antibodies after vaccination.

There are six groups of volunteers: 

(1) those who got two doses of CoronaVac (SV+SV); 

(2) those who got two doses of AstraZeneca (AZ+AZ); 

(3) those who got CoronaVac and followed it with AstraZeneca (SV+AZ); 

(4) those who get AstraZeneca, followed by CoronaVac (AZ+SV); 

(5) those who got two doses of CoronaVac, followed by Covilo (SV+SV+Sinopharm); and 

(6) those who got two doses of CoronaVac, followed by AstraZeneca (SV+SV+AZ).

The research indicates that each group of volunteers has a different immunity level to the Delta variant. 

- The mix and match vaccine SV+AZ has higher immunity than SV+SV and is equal to AZ+AZ but takes a shorter time. 

- The vaccination with two doses of CoronaVac and followed by the AstraZeneca as a booster dose can stimulate 11 times the immunity level

- The third dose, a boost with Sinopharm, can stimulate 2.5 times the immunity level. 

The department has reassured the public that the vaccine combinations SV+AZ and SV+SV+AZ are safe and proper for the current situation in Thailand. They will research the immunity level for the Beta variant in the next phase to collect more data for managing vaccinations with the most effectiveness for the public.

Source: https://bit.ly/3svyWM1